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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Somatropin
Research Papers that Mention the Interaction
“With rhGH , the intestinal absorption of leucine and glutamine increased (P = 0.036) and correlated with serum insulin (r = 0.91, P = 0.002).”
Growth hormone enhances fat-free mass and glutamine availability in patients with short-bowel syndrome: an ancillary double-blind, randomized crossover study.“ rhGH infusion significantly accelerated the inward transport rates of phenylalanine and leucine and protein synthesis, whereas the muscle protein degradation rate and cathepsin B and UbB polyubiquitin mRNA levels were not significantly modified by rhGH.”
“ hGH , when coincubated with hGH ( L ) 108-129, blocked the mitogenic response of the peptide.”
“The individual bone ages were negatively correlated with the hGH induced changes in leucine turnover (r=−0.77;P<0.003) as well as with the urinary pseudouridine concentrations (r=−0.87P<0.0002).”
“In a double-blind, placebo-controlled clinical trial, somatropin 0.1 mg/kg/day, administered for 12 weeks, significantly increased L ”
Recombinant Mammalian Cell-Derived Somatropin
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