Possible Interaction: Leucine and Serotonin

“Injection of the same dose of serotonin inhibits incorporation of [3H]leucine into hippocampal proteins.”

“ Serotonin induced exacerbated coronary vasoconstriction in group High L that was completely reversed by dietary oxysterols.”

“The results show that serotonin significantly diminishes the uptake and steady-state tissue accumulation and the mucosal to serosal flux of L-leucine.”

“… L and P … concentration of 5-HT was increased over its physiological range of 1-10 nM. Lowering the concentration of external calcium from 1 x 10(-3) …(-5) M increased both P and L. However, the effect on L was apparent only at low levels of 5-HT.”

“MIF-I, as well as L-leucine and Pro-Leu, antagonized the contractile response of the ileum to 5-hydroxytryptamine (5-HT).”

“The present study confirms these findings and shows that the ejp'… from impulses in motoneuron L. This study further shows that 5-HT acts by hyperpolarizing and reducing … membrane resistance of neuron L , thus inhibiting the motoneuron and reducing the frequency … spontaneous ejp's on body wall muscle cells.”

“Administration of leucine also decreased the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the brain.”

“Vasodilators or serotonin increased L , but had little effect on RT or RD.”

“The incorporation of radioactive leucine into proteins of several regions of the brain, including cerebral cortex, basal ganglia and diencephalon, midbrain, and cerebellum, was significantly inhibited within 20 min following 5-HT administration.”

“On the other hand, rats fed 5 per cent or 8 per cent L-leucine in their diets for 30 days showed a 22 per cent decrease in brain 5-HT below that of littermates fed a normal diet (YUWILER and GELLER, 1965).”