Possible Interaction: Leucine and Serine

“Mutation of serine to other amino acids with varying side chains: alanine, methionine, leucine , aspartic acid, asparagine, and arginine also resulted in significant activation, indicating a serine-specific inhibitory effect.”

“Competition studies revealed that the small neutral amino acids tyrosine, cysteine, glycine, serine, alanine, methionine, and leucine inhibited Hcy uptake in both cell types, but the inhibition was greater for tyrosine, serine , glycine, and alanine in HAECs.”

“It is possible that steric alterations caused by substitution of serine with leucine at this position may be overcome with high cofactor concentrations.”

“…,serine and … inhibited [3H]leucine release in parallel to the extent of amino-acid-induced liver-mass increase; however, the inhibition of [3H]leucine release was about twice that found when comparable degrees of cell swelling were induced either by hypotonic exposure or by addition of glutamine or glycine.”

“Incorporation of [3H]leucine into protein was increased fourfold within 1 h by incubation with serine.”

“At buried sites in β-strands, the content of Tyr, Trp, Gln and Ser correlates negatively with the content of Val, Ile and Leu (correlation coefficient = −0.93). "”

“In the absence of isoleucine and valine, however, growth is severely inhibited by both L-serine and L-leucine.”