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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Leucine and Quinacrine

supplement:

Leucine

Research Papers that Mention the Interaction

Mepacrine inhibited the uptake and the incorporation of leucine , thymidine and uridine into acid‐insoluble material in human lymphocytes stimulated by phytohaemagglutinin (PHA) in vitro.
The Journal of pharmacy and pharmacology  •  1981  |  View Paper
Extracellular application of mepacrine significantly inhibited I(Ca, L ) in a tonic- and use-dependent manner.
Our results demonstrate that mepacrine strongly inhibits cardiac I(Ca, L).
While mepacrine is a phospholipase A(2) inhibitor and reduces cAMP production, its inhibitory effect on I(Ca, L ) mainly results from a direct block of the channel.
European journal of pharmacology  •  2000  |  View Paper
Mepacrine , an inhibitor of both phospholipases A2 and C, canceled stimulatory actions of L-leucine and KIC on protein synthesis.
Cytotechnology  •  2004  |  View Paper
Mepacrine, … L-leucine and KIC on protein synthesis, suggesting a possible involvement of either arachidonic acid metabolism by phospholipase A2, cyclooxygenase or lipoxygenase, or phosphatidylinositol degradation … indomethacin, an inhibitor of cyclooxygenase, nor caffeic acid, an inhibitor of lipoxygenase, diminished their stimulatory actions, suggesting no involvement of arachidonic acid metabolism.
Cytotechnology  •  2004  |  View Paper