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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Leucine
drug:
Quinacrine
Research Papers that Mention the Interaction
“ Mepacrine inhibited the uptake and the incorporation of leucine , thymidine and uridine into acid‐insoluble material in human lymphocytes stimulated by phytohaemagglutinin (PHA) in vitro.”
Inhibition of lymphocyte transformation by mepacrine and chloroquine“Extracellular application of mepacrine significantly inhibited I(Ca, L ) in a tonic- and use-dependent manner.”
“Our results demonstrate that mepacrine strongly inhibits cardiac I(Ca, L).”
“While mepacrine is a phospholipase A(2) inhibitor and reduces cAMP production, its inhibitory effect on I(Ca, L ) mainly results from a direct block of the channel.”
Mechanism of suppression of cardiac L-type Ca(2+) currents by the phospholipase A(2) inhibitor mepacrine.“ Mepacrine , an inhibitor of both phospholipases A2 and C, canceled stimulatory actions of L-leucine and KIC on protein synthesis.”
Involvement of Protein Kinase C Activation in L-Leucine-Induced Stimulation of Protein Synthesis in L6 Myotubes“ Mepacrine, … L-leucine and KIC on protein synthesis, suggesting a possible involvement of either arachidonic acid metabolism by phospholipase A2, cyclooxygenase or lipoxygenase, or phosphatidylinositol degradation … indomethacin, an inhibitor of cyclooxygenase, nor caffeic acid, an inhibitor of lipoxygenase, diminished their stimulatory actions, suggesting no involvement of arachidonic acid metabolism.”
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