Possible Interaction: Leucine and Propofol

“Group L was found to have significantly less pain on the injection of propofol (mean VAS, 2.5 ± 2.9) (mean ± sd) than group M (mean VAS, 3.8 ± 3.2; P = 0.002).”

“The incidence of pain following propofol injection was significantly reduced in group HP (50%) and group L (55%) compared with group LP (92.5%) (P < 0.05, respectively).”

“… propofol administered until … and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or … intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups.”

“Pretreatment with 10 mg/kg of N-nitro-L: -arginine methyl ester L : -NAME) but not aminoguanidine significantly inhibited the change in vascular permeability after challenge with propofol.”

“These results indicated that propofol , at concentrations greater than those that are clinically relevant, shortened APD mainly by suppression of ICa, L , and the biphasic effects on APD by thiopentone were caused by depression of IK, and concomitant suppression of ICa,L and IK1 at higher concentrations.”

“… propofol … L were significantly higher than that in group N. More patients suffered hypoxemia in group N than in group C and group L. Then, less … and cough in group N. Pretreatment with nalbuphine 0.1 mg/kg was effective in reducing propofol-induced injection pain and propofol consumption.”

“Compared with the NS + P group, the ED50 of propofol induction dose was significantly reduced in the L + P group (2.01 mg/kg vs. 1.69 mg/kg) (U = 61.5, p < 0.001).”

“Results A significant decrease in the incidence of pain on propofol injection was achieved in group L (37%) and group B (23%) compared to either group T (80%) and group S (83%) (P < 0.001).”