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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Leucine and Propafenone

supplement:

Leucine

Research Papers that Mention the Interaction

A range of propafenone concentrations were applied which reduced ICa, L in a dose-dependent manner (IC50 1.7 microM).
Also, the recovery of ICa L from inactivation was slowed by propafenone.
In the presence of propafenone , the voltage-dependence of inactivation of ICa, L was shifted 8 mV in the hyperpolarizing direction.
When test pulses were applied to a range of potentials, propafenone reduced ICa, L at each potential without significantly affecting the activation curve for this current.
British journal of pharmacology  •  1997  |  View Paper