Possible Interaction: Leucine and Proline

“Our results confirm that the previously described alanine 113 to proline substitution is responsible for the altered properties of TBG-M. The substitution of leucine 227 by proline in TBG-CD5 appears to impair its cotranslational processing and secretion.”

“Substitution of proline , a helix-destabilizing amino acid, for leucine (residue 8) of a predicted amphipathic alpha-helix (residues 3-12), IFN gamma (1-39) [Pro]8, resulted in a substantial reduction in the helical content of the peptide, supporting the presence of helical structure in this region.”

“The replacement of leucine by proline will likely impair the structure breaking helix G and causing instability of the molecule and the clinical manifestations typical of unstable Hbs.”

“Progression of renal insufficiency (RI) was worse in patients with Leu at codon 10 (LeuLeu vs. LeuPro p < 0.01, LeuLeu vs. ProPro ; p < 0.01).”

“However, substitution of either aspartic acid 202 with valine or proline 203 with leucine dramatically inhibited WHV production.”

“Codon 344 is a key residue within the tetramerisation domain, and the amino acid substitution of a proline for a leucine is predicted to have profound implications for tetramerisation and potentially DNA binding.”

“We found highly significant correlations between the δ15N ratios of leucine to the δ15N ratios of glutamic acid, proline , alanine, tyrosine and aspartic acid at oligotrophic sites of enhanced nitrogen fixation.”

“Substitution of a leucine for a proline at position 281 in phenylalanine hydroxylase increases the Km for phenylalanine >20‐fold over that of the wild‐type.”

“Alanine, … and proline … [3H]leucine release in parallel to the extent of amino-acid-induced liver-mass increase; however, the inhibition of [3H]leucine release was about twice that found when comparable degrees of cell swelling were induced either by hypotonic exposure or by addition of glutamine or glycine.”

“Combinations of leucine (0.5 mM) with either alanine, glutamine, asparagine or proline (2 mM) inhibited proteolysis by 40-50%.”