Possible Interaction: Leucine and Phospholipids

“from the N-terminus of SP-C, with added stretches of leucines and lysines to create an -helix-like conformation, improved in vitro and in vivo function in premature rabbit fetuses when mixed with phospholipids.”

“The polyunsaturated fatty acids (PUFA) and peroxidation index (PI) in phospholipids were increased by the L and OCL treatments (P=0.007 and P=0.003, respectively).”

“At d 30, group L significantly increased plasma cholesterol esters (+57%) and phospholipids (+35%) compared with group C. It also increased plasma n-3 PUFA (4.7-fold increase) to the detriment of n-6 PUFA (-30%), leading to a higher peroxidizability index (+20%).”

“Although both cardiolipin and phosphatidylserine are inhibitors of the enzyme, only the inhibition by the former phospholipid is reversed by L-leucine.”

“Dihomo-gamma-linolenic acid (20:3n-6) and arachidonic acid in aorta phospholipids increased by the E + L treatment.”

“Regardless of the nutritional state, L-leucine strongly reduced the oxidation of palmitate and increased its incorporation into islet triacylglycerols and phospholipids at 3 mM glucose.”

“Preincubation for 23 hr of confluent chick embryo heart cell cultures with increasing doses of a phospholipidic complex produces a progressive increase of [14C] leucine uptake and of its incorporation into proteins when compared to control cultures maintained with 0.5% foetal calf serum.”

“These metabolomic measurements show how the metabolism of isoleucine and leucine , rather than the selectivity of FabH, control the structure of membrane phospholipids.”

“Peptides of 21 residues, synthesized following the sequence of SP-B or resembling the hydrophobic and hydrophilic domains of SP-B (such as RLLLLRLLLLRLLLLRLLLLR, R, Arg, and L , Leu), enhanced the abilities of phospholipids to reduce surface tension both in vitro and in vivo.”