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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Phenylephrine
Research Papers that Mention the Interaction
“… phenylephrine , the mean(SD) MAP, SV, CO, …) mL, 1.02(0.74) L min−1, 3(2.6) mmHg and 4.0(1.6) mmHg at T5 respectively, while both dynamic … to 9% at T5 and to 13% at T10 and SVV from 19 to 11 and 14%, respectively.”
Phenylephrine increases cardiac output by raising cardiac preload in patients with anesthesia induced hypotension“Contrastingly, rS ps O 2 at … 4 , T 9 –T 10 and L 1 –L 2 … PE (0.4% ± 2.5, 0.7% ± 2.0 and – 0.1% ± 1.4, respectively), while it … E administration (– 1.3% ± 3.4%, – 0.7% ± 2.6% and – 1.3% ± 2.7%, respectively).”
“ PE (…, L (51.3%; n= 40) and shifted peak ICa,L activation voltage by −10 mV. PE‐induced stimulation of ICa,L was blocked by each … ODQ, 2 μm H‐89 or 10 μm LY294002, and was unaffected by 10 μm chelerythrine or incubating cells in pertussis toxin (PTX).”
Phenylephrine acts via IP3‐dependent intracellular NO release to stimulate L‐type Ca2+ current in cat atrial myocytes“ Phenylephrine increased the ICa, L by 60.8±21% (n=5) during the positive inotropic phase.”
“Agonist treatment with phenylephrine hydrochloride (10 µM) resulted in altered levels of several metabolites including myo-inositol, glucose, fructose, alanine, leucine , phenylalanine, valine, and n-acetylglutamic acid.”
The potential of metabolomic analysis techniques for the characterisation of α1-adrenergic receptors in cultured N1E-115 mouse neuroblastoma cells
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