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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Phenobarbital
Research Papers that Mention the Interaction
“The results indicate that diphenylhydantoin and phenobarbital inhibit the incorporation in vivo of radioactive leucine in the rat cortex when plasma drug levels have been attained that are therapeutically rational in the human, and substantial inhibitions would probably occur after much lower doses in the rat.”
Effects of diphenylhydantoin and phenobarbital on protein metabolism in the rat cerebral cortex.“When a 40 min pulse of labeled leucine was given 24 hrs after a single injection of Pb (75 mg/kg), there was a 42% stimulation in the specific activity of microsomal protein but an 87% enhancement, compared to control, in the nuclear protein fraction.”
“The 90-min incorporation of l-leucine-3H into microsomal NADPH-cytochrome c reductase was increased 2- to 3-fold in mice pretreated for 2 or more days with sodium phenobarbital.”
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