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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Leucine
drug:
Paclitaxel
Research Papers that Mention the Interaction
“… leucine or valine … with paclitaxel while preserving the responsiveness to lipid IVa and lipid A. This suggests specific interaction of paclitaxel with F126 because its replacement with … activation by lipid A. These results provide an insight into the molecular mechanism of TLR4 activation by two structurally very different agonists.”
Tetraacylated Lipid A and Paclitaxel-Selective Activation of TLR4/MD-2 Conferred through Hydrophobic Interactions“Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT).”
“Lapatinib L ) a dual, inhibitor of EGFR and HER2/neu tyrosine kinase activity improves overall survival (OS) in patients with metastatic BC when added to paclitaxel (SABCS 2010:P3-1424).The relative efficacy of L + taxane compared to trastuzumab (T) + taxane in the metastatic setting is unknown.”
Phase III study of taxane chemotherapy with lapatinib or trastuzumab as first-line therapy for women with HER2/neu-positive metastatic breast cancer (BC) (NCIC Clinical Trials Group (NCICCTG)MA.31/GSK EGF 108919).
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