Possible Interaction: Leucine and Nitrogen

“In conclusion, the response of leucine kinetics to feeding is modified by the molecular form of nitrogen intake , with the oligopeptides inducing a higher oxidation and protein synthesis and a lesser inhibition of protein breakdown.”

“Intakes of TN were positively correlated with plasma concentrations of VAL, LEU , ILE, tyrosine (TYR), histidine (HIS), and SUN (r=0.38-0.64, p<0.05-0.001), and negatively correlated with plasma arginine concentrations (r=-0.41, p<0.05).”

“More importantly, the ingestion of significant amounts of leucine by normal subjects, presumably in optimal nitrogen balance, results in a net loss of nitrogen from muscle.”

“ Nitrogen intake decreased as dietary CP concentration decreased (114.3, 106.0, 107.4, and 99.0 ± 5.29 g/d and 169.5, ….3, 161.2, and 145.1 ± 5.29 g/d for HCP, MHCP, MLCP, and LCP in early and peak lactation, respectively; L : < 0.05).”

“ Nitrogen infusion significantly decreased maternal anf fetal PaO2 at 4 L X min-1.”

“In young adult rats fed on leucine supplemented o2 diet, excretion of urinary nitrogen increased significantly compared with o2 diet alone, suggesting that a slight amino acid imbalance took place.”

“In conclusion, L-leucine increases GDH activity and stimulates glutamate synthesis from different nitrogen sources by regulating mTORC1/SIRT4 pathway in the liver of pigs.”