Possible Interaction: Leucine and Nitric Oxide

“Moreover, ADMA, l‐NMMA and l‐leucine were effective inhibitors of NO synthesis in both hypertensive and control platelets.”

“Additionally, when nitric oxide is available, leucine increases the migration of intestinal cells.”

“ NO inhibits I(Ca, L ), only when I(Ca,L) had been activated by sympathetic nervous system stimulation via antagonistic action between cAMP/protein kinase A and cGMP/protein kinase G/phosphodiesterase signals.”

“For instance, in rabbit sinoatrial myocytes, NO inhibits the beta-adrenergic stimulation of I(Ca, L ) through activation of PDE2.”

“In cat and human atrial myocytes, NO potentiates the cAMP-dependent stimulation of I(Ca, L ) through inhibition of PDE3.”

“These data suggest that high concentrations of NO injure HCMFs and inhibit ICa, L through the PKG and PKA signalling pathways but not through the S‐nitrosylation pathway.”

“Nitric oxide synthase activity and NO pool were higher in groups L and PS than in group C (p=0.010).”

“The levels of NO in air exhaled at 0.17 L x s(-1) through either nostril separately were higher than in air exhaled at the same flow rate through both nostrils simultaneously.”

“Inhaling 100 ppm NO increased FEV1 to 2.66 +/- 0.18 L (p < 0.01), and this increase was maintained after NO was discontinued.”

“… L-leucine inhibits nitric oxide synthesis by endothelial cells (EC), we hypothesized that dietary supplementation with AKG (a substrate for BCAA transaminase) may stimulate BCAA catabolism in the small intestine and extra-intestinal tissues, thereby reducing the circulating concentrations of BCAAs and increasing nitric oxide synthesis by endothelial cells.”

“ NO stimulates ICa, L via cGMP‐mediated cAMP‐dependent PKA signalling.”