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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Neuropeptide Y
Research Papers that Mention the Interaction
“10% of MBH NPY neurons were inhibited by l-leucine , and leucine rapidly reduced AGRP secretion, providing a mechanism for the rapid leucine-induced inhibition of foraging behavior in rodents.”
Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights“The decreased food intake observed in fish treated intracerebroventricularly with leucine could relate to changes in mRNA abundance of hypothalamic neuropeptides [proopiomelanocortin (POMC), cocaine- and amphetamine-related transcript (CART), neuropeptide Y ( NPY ), and agouti-related peptide (AgRP)].”
Evidence for the presence in rainbow trout brain of amino acid-sensing systems involved in the control of food intake.“Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P < 0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels.”
Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks
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