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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Leucine and Neuropeptide Y

supplement:

Leucine

Research Papers that Mention the Interaction

10% of MBH NPY neurons were inhibited by l-leucine , and leucine rapidly reduced AGRP secretion, providing a mechanism for the rapid leucine-induced inhibition of foraging behavior in rodents.
Molecular metabolism  •  2018  |  View Paper
The decreased food intake observed in fish treated intracerebroventricularly with leucine could relate to changes in mRNA abundance of hypothalamic neuropeptides [proopiomelanocortin (POMC), cocaine- and amphetamine-related transcript (CART), neuropeptide Y ( NPY ), and agouti-related peptide (AgRP)].
American journal of physiology. Regulatory, integrative and comparative physiology  •  2018  |  View Paper
Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P < 0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels.
Journal of Animal Science and Biotechnology  •  2012  |  View Paper