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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The leucine substitution at residue 275 was found to significantly decrease the affinity towards the physiological reducing substrate, NADH , without affecting the activity of the P275L variant.”
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding.“The effects of GTP and 2-oxoglutarate in potentiating inhibition by NADH can account for their effects in enhancing the apparent activation by L-leucine.”
Activation of glutamate dehydrogenase by L-leucine.“These results indicate that beta cell metabolism of monomethyl succinate and leucine , like glucose, influences dehydrogenases that produce NADH.”
“ NADH concentrations were also increased by leucine.”
“ Leucine also stimulated mitochondrial biogenesis genes SIRT-1, PGC-1α and NRF-1 as well as mitochondrial component genes UCP3, COX, and NADH expression by 3–5 fold in C2C12 cells (p < 0.003).”
Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes“The uptake rates of K(+), 3-O-methylglucose, leucine , and arginine were all decreased in the presence of NADH.”
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