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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Low-dose (…) NAD+ precursors (nicotinic acid, nicotinamide … nicotinamide riboside) synergized with leucine to increase Sirt1 activity in adipocytes, hepatocytes, and muscle cells (30-100%, P < .01) and lifespan in Caenorhabditis elegans (…%, P = .025) and to significantly regress atherosclerotic lesion size and macrophage infiltration in a mouse model of atherosclerosis.”
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.“Here we show that leucine exerts a direct effect on Sirt1 kinetics, reducing its Km for NAD+ by >50% and enabling low doses of resveratrol to further activate the enzyme (p = 0.012).”
“Disturbances in tryptophan-nicotinamide adenine dinucleotide pathway , seen in pellagrins whose staple is sorghum have been ascribed to an amino acid imbalance caused by excess intake of leucine.”
“The inactivation was completely prevented in the copresence of L-leucine and NAD+.”
Leucine dehydrogenase from Bacillus stearothermophilus: identification of active-site lysine by modification with pyridoxal phosphate.
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