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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Similarly, administration of leucine enkephalin enhanced the development of acute tolerance and dependence produced by a single dose of morphine.”
Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.“RESULTS:Mean morphine consumption was significantly lower in group L than in group M during the first 48 postoperative hours: 26 ± 15 vs 54 ± 29 mg, i.e., a mean difference for each 24-hour period of 14.2 (95% confidence interval [CI] 7.6 to 20.9) mg.”
“ Morphine consumption in Group L were significantly lower than in Group M at 2, 3, 6, 8, 24, 36 and 48th postoperative hours (p<0.05).”
“The dose of morphine by titration was larger in Group L than in Group S (0.28 [0.04–0.38] mg/kg versus 0.16 [0.03–0.41] mg/kg; P < 0.05).”
“ Morphine consumption in groups L and K was significantly lower than in group C. Pre-emptive administration of lornoxicam and ketoprofen effectively reduced post-operative pain and morphine consumption, and lornoxicam was more effective than ketoprofen in the early post-operative period.”
“In the stressed rats, morphine potentiated the stress-induced elevation of 5HIAA content in the striatum and attenuated the stress-induced elevation of 5HIAA in the PM and L , and that of 5HT in the PM, remaining 5HIAA content in FCP and FCM unaltered.”
[Effects of morphine and diazepam pretreatment on immobilization stress-induced increase of serotonin metabolism in discrete brain areas of the rat].“The inhibition of protein synthesis caused by acute administration of morphine was calculated to be greater than previously reported since morphine treatment increased the specific radioactivity of the free pool of leucine in brain following the intracisternal injection of the labelled amino acid.”
“The rate of removal of the labeled leucine from the free amino acid pool of brain and the rate of incorporation of labeled leucine into protein were decreased in the animals injected either with a single dose of morphine or with daily injections for 5 days.”
“ Morphine consumption was also less in group U (4.72 ± 0.94 mg) than group L (5.57 ± 2.53 mg) (P = 0.049).”
Comparison of laparoscopy-guided with ultrasound-guided subcostal transversus abdominis plane block in laparoscopic cholecystectomy – A prospective, randomised study“Median total morphine consumption over 24 and 48 postoperative hours of Group A were significantly less than Group L (6/10 mg vs 13/25 mg, p, 0.008 and 0.001, respectively).”
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