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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Methotrexate
Research Papers that Mention the Interaction
“At 6 months the median decline in forced expiratory volume in 1 second from the time methotrexate therapy was started was 0.1 +/- 0.2 L , or 3% +/- 11%.”
Methotrexate can halt the progression of bronchiolitis obliterans syndrome in lung transplant recipients.“Addition of 1 muM methotrexate to cultures of L5178Y cells results in an initial inhibition of thymidine, uridine, and leucine incorporation into acid-insoluble material followed, after about 10 hr, by a partial recovery in the extent of incorporation of these precursors.”
Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.“Determination of mitochondrial protein synthesis in the presence of methotrexate shows a considerable decrease in incorporation of radioactive leucine before any significant induction of petites has taken place.”
Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate
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