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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Leucine and Methotrexate

supplement:

Leucine

Research Papers that Mention the Interaction

At 6 months the median decline in forced expiratory volume in 1 second from the time methotrexate therapy was started was 0.1 +/- 0.2 L , or 3% +/- 11%.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation  •  1996  |  View Paper
Addition of 1 muM methotrexate to cultures of L5178Y cells results in an initial inhibition of thymidine, uridine, and leucine incorporation into acid-insoluble material followed, after about 10 hr, by a partial recovery in the extent of incorporation of these precursors.
Cancer research  •  1975  |  View Paper
Determination of mitochondrial protein synthesis in the presence of methotrexate shows a considerable decrease in incorporation of radioactive leucine before any significant induction of petites has taken place.
Molecular and General Genetics MGG  •  2004  |  View Paper