A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man.

The present findings demonstrate that intravenous infusion of

 (not infusion of valine or isoleucine) results in marked reductions in the concentrations of the aromatic amino acids and 

Sterilization by Adaptive Immunity of a Conditionally Persistent Mutant of Mycobacterium tuberculosis

 and pantothenate starvation metabolically blocked the sterilization mechanisms of 

 starvation but not those of arginine starvation.

Protein synthesis in mature human oocytes.

, efflux of radiolabeled methionine from preloaded oocytes into medium containing methionine and uptake of methionine in medium with low sodium ion concentration was observed.

Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus

 led to greater regulation than either L alone or L and S. Coexpression of all three envelope proteins was also found to limit completion of plus-strand DNA synthesis, and the degree of this effect correlated with the level of the proteins and virion secretion.

Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein.

 led to increased propensity for aggregation (soluble oligomers) but slower formation of fibrils.

Individual differences in chromatic (red/green) contrast sensitivity are constrained by the relative number of L- versus M-cones in the eye

 ratio should also influence red/green chromatic contrast sensitivity.

Insights from gene arrays on the development and growth regulation of uterine leiomyomata.

Prominent among the 78 genes down-regulated in

 were alcohol dehydrogenases 1alpha-gamma, tryptase, dermatopontin, thrombospondin, coxsackievirus receptor, nur77, and c-kit.

Impact of beverage acceptability on fluid intake during exercise

 exceeded W by 318% and 233%, respectively.

Partial deficiency of dystrophin‐associated proteins in a young girl with sporadic myopathy and normal karyotype

Confounding bright, but Congo-red-negative, polarization of connective tissue in H a n d

 is blocked by fluorescence filters ( I and 

Effect of leucine on amino acid and glucose metabolism in humans.

Plasma concentrations of essential amino acids, including threonine,

, isoleucine, valine, tyrosine, and phenylalanine were significantly decreased by 

Expression of amino acid transport systems in cultured human umbilical vein endothelial cells.

 was markedly inhibited during perfusion with 1 mM‐BCH (beta‐2‐aminobicyclo‐(2,2,1)‐heptane‐2‐carboxylic acid, system L analogue), L‐leucine, D‐leucine, L‐phenylalanine, 

Protein Synthetic Patterns in Immature and Mature Human Oocytes a

Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects.

 its concentration rose four- to six-folds, while the concentrations of several other amino acids declined continually, the effect being most pronounced for isoleucine (-55% of initial value), 

 (-55%), valine (-40%), tyrosine (-35%) and phenylalanine (-35%).

 by the brain, seen in the basal state, was inhibited during 

Leucine-induced promotion of post-absorptive EAA utilization and hepatic gluconeogenesis contributes to protein synthesis in skeletal muscle of dairy calves.

 resulted in increased concentrations of glucose, 

, threonine, histidine and EAAs and decreased concentration of arginine in serum.

Waveforms From Stylet Probing of the Mosquito Aedes aegypti (Diptera: Culicidae) Measured by AC–DC Electropenetrography

A kinetogram of conditional probabilities for waveform performance demonstrated plasticity among individuals in

Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.

 significantly affected β-casein expression (P < 0.01).

Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure

Pretreatment of HF myocytes with a nitric oxide (NO) synthase inhibitor (L-NAME,

) resulted in a significantly greater increase in ICa,

 (28%, 8.4 ± 0.1 versus 6.5 ± 0.1 pA/pF, p < 0.01) during Ang-(1-7) superfusion.

Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter

 concentration in cells promotes the influx of BCAAs, 

, phenylalanine, and tyrosine into cells through the LAT.

 regulates the plasma concentrations of branched-chain amino acids, 

, phenylalanine, and tyrosine, and that system L amino acid transporters are involved in the leucine action.

Horizontal Cell Feedback without Cone Type-Selective Inhibition Mediates “Red–Green” Color Opponency in Midget Ganglion Cells of the Primate Retina

Midget” ganglion cells of the retina use center–surround receptive field structure to combine

 signals antagonistically and thereby establish a “red–green, color-opponent” visual pathway.

Neutral amino acid symport in larval Manduca sexta midgut brush-border membrane vesicles deduced from cation-dependent uptake of leucine, alanine, and phenylalanine.

A 20-fold excess of unlabeled leucine, isoleucine,

, valine, alanine, lysine, histidine, phenylalanine, and glutamine inhibited uptake of 

 and phenylalanine, and six of these amino acids inhibited uptake of alanine, by more than 50% both in the presence and absence of a potassium ion gradient.

Interactions among amino acid transport systems in snail Helix aspersa intestine.

 is clearly inhibited by high concentrations (40 mM) of 

, and not by proline or lysine, whereas the last two amino acids inhibit cycloleucine uptake.

Quantitative aspects of protein synthesis in non-cultured and cultured rabbit blastocysts.

 was incorporated on a 5.5-fold higher level than 

Effects of excess leucine on growth and tryptophan and niacin metabolism in rats.

 intake decreased the levels of valine, isoleucine, 

 and leucine in the liver, but these changes were not observed in niacindeficient rats.

Intestinal handling of two tetrapeptides by rodent small intestine in vitro.

 and of Ala from the tetrapeptides was strongly inhibited by 

, as was uptake of these amino acids from free solution.

Leishmania tropica: regulation and specificity of the methionine transport system in promastigotes.

l -Ethionine and l -norleucine, as well as a number of neutral, nonpolar amino acids 

, isoleucine, valine, and alanine) also inhibit 

Physiological control of brain catechol synthesis by brain tyrosine concentration.

Similarly, the neutral amino acids, valine and isoleucine (which have been used previously to modify brain tyrosine concentrations and, hence, catechol synthesis), had no effect on tyrosine hydroxylase activity in vitro in concentrations up to 10−3 M. At high concentrations 

Action of ethionine, methionine, ATP, adenine, albumin and Ca 2+ on protein synthesis of normal and tumor cells.

 incorporation into liver protein are less than those of ethionine.

A cross-inhibition of basic amino acid transport by neutral amino acids.

 produced a large competitive stimulation of lysine transport, while arginine under the same conditions was inhibitory.

Leucine transport by rat liver mitochondria in vitro.

, valine, and cycloleucine) both significantly inhibited 

 uptake and effected a rapid discharge of leucine from mitochondria pre-loaded with the amino acid.

Discrimination of Single Transport Systems

In contrast, the Na+-insensitive uptake of

 is concentrative and subject to inhibition by such amino acids as phenylalanine, 

, and valine, although not in a manner to indicate that the uptake is mediated by a single agency.

PERMEATION OF AMINO ACIDS IN MONILIFORMIS AND MACRACANTHORHYNCHUS (ACANTHOCEPHALA).

 by both sexes of Moniliformis is inhibited by alanine, serine, 

, and isoleucine-these inhibitions are reciprocal.

Effect of Met/Leu substitutions on the stability of NAD+-dependent formate dehydrogenases from Gossypium hirsutum.

 on the position of 243 increased the free energy gain by 670 J mol-1.

Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs.

Compared to l-methionine residues, use of

 homologs allow improved copolymerization with 

 to give well-defined block copolypeptides.

Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men

 is a regulator of the plasma concentrations of BCAAs, 

Bicomponent hydrogels of lumichrome and melamine: photoluminescence property and its dependency on pH and temperature.

FTIR spectra suggest that H-bonding between

 produces the supramolecular complex, and (1)H NMR spectra suggest that pi-stacking of the complex produce fibrillar network structure entrapping a large amount of water producing the hydrogels.

cMET expression in HER2+ MBC patients with first-line lapatinib (L) treatment.

 correlates with poor prognosis in breast cancer (Garcia et al., 2007) and is a factor associated with decreased sensitivity to 

 in HER2+ breast tumor cell lines in vitro (Liu et al., submitted).

Depth related amino acid uptake by Prochlorococcus cyanobacteria in the Southern Atlantic tropical gyre.

 (0.2-0.65 nM) were about 2 times higher than the concentrations of 

, while the turnover rates of the two amino acids were remarkably similar (0.1-0.7 nM d(-1)).

Amino Acid Transport in Suspension-cultured Plant Cells: II. CHARACTERIZATION OF l-LEUCINE UPTAKE.

 uptake in the three saturable phases was inhibited by a 20-fold higher concentration of 18 other amino acids; phenylalanine, alanine, and 

 were the most effective inhibitors, whereas aspartic acid, asparagine, histidine, and arginine were the least effective.

Methionine transport in Salmonella typhimurium: evidence for at least one low-affinity transport system.

There appeared to be at least two additional transport systems with relatively low affinities for methionine in the metP763 mutant strain, with apparent Km values for methionine of 24 microM and approximately 1.8 mM. The latter system, with a very low affinity for

Mechanism of inhibition of Chromatium D growth by L-methionine. Regulation of L-threonine biosynthesis by the intracellular level of S-adenosylmethionine.

, L-phyenylalanine and L-valine (Type I) inhibited the 

 and consequently prevented the bacterium from the unusual accumulation of S-adenosyl-L-methionine even in the presence of L-methionine in the medium.

Contamination of Commercial l-Leucine Preparations with Methionine and Cystine

129:609, 1939), I was surprised to find that certain current preparations of commercial

, supposedly of high quality, are heavily contaminated with 

When it was observed that only cultures of group D could grow on DL-leucine, it became apparent that even the "methioninefree"

Changes in intestinal and serum alkaline phosphatase levels during absorption of certain amino acids.

 on the other hand produced a highly significant depression of the …) Serum inorganic phosphorus levels were significantly decreased after ingestion of glycine, 

, serine, threonine, methionine, glutamic acid, histidine, phenylalanine, tyrosine, and tryptophan.(d) Serum α-… in all cases except with cystine and lysine, when no change wa...

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Possible Interaction: Leucine and Methionine

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Research Papers that Mention the Interaction