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“Meropenem treatment was accompanied by a dramatic accumulation of unlinked pentapeptide stems with no change in the tetrapeptide pools, suggesting that meropenem inhibits both a D,D‐carboxypeptidase and an L ,D‐transpeptidase.”
“It was observed that imipenem and meropenem inhibit activity of this enzyme, responsible for generating L ,D-transpeptide linkages in the peptidoglycan layer of Mycobacterium tuberculosis.”