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“The results demonstrated the use of the appropriate excipients leucine , poly-vinyl-alcohol, cyclodextrine) and solvent combination (ethanol-water) during the co-spray drying, increases the inhalation properties of the mannitol.”
“The presence of L- leucine in mannitol containing formulations decreased the interparticulate forces between particles and increased significantly the process yield and fine particle fraction (FPF).”
Research in pharmaceutical sciences • 2017 | View Paper
“It was concluded that demixing … the binary mixture of L‐leucine … D‐mannitol from the observation that the sampling errors indicated by the standard deviations of measured leucine mass fractions increased … mixing, and the standard deviation values were all larger than the theoretical lower limit determined by the simulation.”