Possible Interaction: Leucine and Lysine

“For clone K3-2, from a different patient, the substitution of lysine for glutamine or isoleucine for leucine in the core region resulted in about 30-fold and 10-fold increases in the stimulatory capacity of the peptides, respectively.”

“Cell proliferation studies evidenced that the spray drying process together with the addition of leucine reduced the cytotoxic effect of ketoprofen lysine salt as raw material, making the ketoprofen lysinate DPI a very promising product for the inflammation control in CF patients.”

“Amino acid substitutions of the leucine at position 107, a critical residue at the fusion loop of E protein, with lysine resulted in severe impairment in infectivity, suggesting that entry of the pseudotype reporter virus is mediated through the fusogenic properties of E protein.”

“ L-leucine uptake by both cell lines was inhibited by L-alanine, D-leucine and to a lesser extent by L-lysine but not by L-proline.”

“Both components … inhibited by L-lysine in a competitive fashion, suggesting that four different systems were responsible for glutamine uptake: B(0), …,+), b(0,+) and L. All four systems were present during the differentiation process, with systems L and B(0) being responsible for … to 80% of glutamine uptake.”

“In solutions containing sodium the entry of lysine through the high‐affinity system (y+L) is inhibited by the neutral amino acids L‐leucine , L‐methionine and L‐glutamine with comparable high affinity.”

“ Leucine and methionine, but apparently not glutamine, inhibit lysine entry through system y+ with a much lower affinity.”

“According to arteriovenous differences across the leg, the net balance of phenylalanine, valine, and lysine shifted toward greater retention during leucine infusion, whereas alanine balance did not change.”

“Substitution of a cationic residue (Arg or Lys ) with Leu or addition of tetra-arginine to the C- or N-terminus of penetratin caused considerable reduction in the enhancing efficiency properties of the modified analogues.”

“The antiviral effect of l-lysine is partially or completely prevented by simultaneous addition of certain amino acids ( l-leucine , l-isoleucine) to the culture medium.”

“The activity of this HMTase was abolished when lysine 9 of N‐terminal histone H3 peptide was replaced by leucine whereas mutation of lysine 4 to leucine inhibited this activity only partially.”