Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Leucine and Lysine

supplement:

Leucine

supplement:

Lysine

Research Papers that Mention the Interaction

For clone K3-2, from a different patient, the substitution of lysine for glutamine or isoleucine for leucine in the core region resulted in about 30-fold and 10-fold increases in the stimulatory capacity of the peptides, respectively.
European journal of immunology  •  2003  |  View Paper
Cell proliferation studies evidenced that the spray drying process together with the addition of leucine reduced the cytotoxic effect of ketoprofen lysine salt as raw material, making the ketoprofen lysinate DPI a very promising product for the inflammation control in CF patients.
International journal of pharmaceutics  •  2013  |  View Paper
Amino acid substitutions of the leucine at position 107, a critical residue at the fusion loop of E protein, with lysine resulted in severe impairment in infectivity, suggesting that entry of the pseudotype reporter virus is mediated through the fusogenic properties of E protein.
Virology  •  2007  |  View Paper
L-leucine uptake by both cell lines was inhibited by L-alanine, D-leucine and to a lesser extent by L-lysine but not by L-proline.
Biochimica et biophysica acta  •  2004  |  View Paper
Both components … inhibited by L-lysine in a competitive fashion, suggesting that four different systems were responsible for glutamine uptake: B(0), …,+), b(0,+) and L. All four systems were present during the differentiation process, with systems L and B(0) being responsible for … to 80% of glutamine uptake.
Biochimica et biophysica acta  •  2000  |  View Paper
In solutions containing sodium the entry of lysine through the high‐affinity system (y+L) is inhibited by the neutral amino acids L‐leucine , L‐methionine and L‐glutamine with comparable high affinity.
Leucine and methionine, but apparently not glutamine, inhibit lysine entry through system y+ with a much lower affinity.
The Journal of physiology  •  1994  |  View Paper
According to arteriovenous differences across the leg, the net balance of phenylalanine, valine, and lysine shifted toward greater retention during leucine infusion, whereas alanine balance did not change.
The American journal of physiology  •  1992  |  View Paper
Substitution of a cationic residue (Arg or Lys ) with Leu or addition of tetra-arginine to the C- or N-terminus of penetratin caused considerable reduction in the enhancing efficiency properties of the modified analogues.
Journal of controlled release : official journal of the Controlled Release Society  •  2010  |  View Paper
The antiviral effect of l-lysine is partially or completely prevented by simultaneous addition of certain amino acids ( l-leucine , l-isoleucine) to the culture medium.
Archiv für die gesamte Virusforschung  •  2005  |  View Paper
The activity of this HMTase was abolished when lysine 9 of N‐terminal histone H3 peptide was replaced by leucine whereas mutation of lysine 4 to leucine inhibited this activity only partially.
Journal of cellular biochemistry  •  2003  |  View Paper
Show More