Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Leucine and Levodopa

supplement:

Leucine

Research Papers that Mention the Interaction

L-leucine decreased the intestinal absorption of levodopa from 40 +/- 19 to 21 +/- 15% but was without effect on the absorption of antipyrine, benserazide and D-glucose.
British journal of clinical pharmacology  •  1993  |  View Paper
High-protein meals or oral phenylalanine, leucine , or isoleucine (100 mg per kilogram of body weight) reversed the therapeutic effect of infused levodopa without reducing plasma levodopa concentrations.
The New England journal of medicine  •  1984  |  View Paper
Incubation of MBH in Krebs-Ringer solution with l-leucine , a competitive inhibitor of l-DOPA uptake, was used to prevent a hypothetical l-DOPA capture into AADC-containing neurons.
Neuroscience  •  2014  |  View Paper