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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Circulating plasma leptin concentrations were higher on days 4 and 7 in L pigs.”
Effect of Administration of Recombinant Human Leptin during the Neonatal Period on the Plasma Concentration and Gene Expression of Leptin in the Piglet“There was a net change from lipogenesis to lipolysis, i.e., fat … (30-40 mg/min, P = 0.0001) from P to L. Serum leptin concentrations had a significant positive correlation with fat oxidation … E (r = 0.76, P = 0.005) and L (r = 0.72, P = 0.009).”
“… leucine treatment during differentiation … of perilipin A, leptin and leptin-related pathway, such as leptin receptor, Janus kinase 2 and suppressor of cytokine signaling-3 (after 0.0 and ….00 ± 0.03) vs. (0.35 ± 0.05) , (1.00 ± 0.06) vs. (0.34 ± 0.05) , P<0.001).”
[Effects of leucine on adipogenesis in 3T3-L1 preadipocytes during and after differentiation].“No treatment effects were observed in adipocytes from the high-energy diet groups, neither in leptin expression nor secretion, except that leptin secretion was significantly reduced by leucine in RE fish adipocytes (p=0.025).”
“Cathepsin L expression and activity were both significantly increased by leptin whereas a cathepsin L peptide inhibitor or siRNA specific for CUX1 completely prevented the leptin-induced increase in FTO expression.”
“Collectively, these results suggest that leptin and leucine synergistically regulate protein metabolism in skeletal muscles both in vitro and in vivo.”
“There were interactions (P< 0·05) between the leucine and leptin treatments with regard to protein metabolism in C2C12 myotubes and soleus muscles of ob/ob mice but not in the gastrocnemius muscles of ob/ob mice.”
“ L-leucine and L-glutamate also strongly stimulated leptin synthesis and secretion.”
“ Leu and norleucine stimulated a rise in plasma leptin ; however, the magnitude was less than the response to a complete meal.”
“VSMC size and [3H]leucine incorporation rates were significantly increased by leptin in stretched and unstretched tissues.”
“Therefore, we concluded that leucine activates leptin expression in adipose cells at the level of translation via a mammalian target of rapamycin (mTOR)-mediated pathway.”
“We found that addition of leucine to isolated rat adipocytes significantly increased leptin production by these cells, suggesting that postprandial leptin levels may be directly regulated by dietary leucine.”
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