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Last Updated: 2 years ago

Possible Interaction: Leucine and Leptin

supplement:

Leucine

drug:

Leptin

Research Papers that Mention the Interaction

Circulating plasma leptin concentrations were higher on days 4 and 7 in L pigs.
Neonatology  •  2005  |  View Paper
There was a net change from lipogenesis to lipolysis, i.e., fat … (30-40 mg/min, P = 0.0001) from P to L. Serum leptin concentrations had a significant positive correlation with fat oxidation … E (r = 0.76, P = 0.005) and L (r = 0.72, P = 0.009).
American journal of physiology. Endocrinology and metabolism  •  2004  |  View Paper
leucine treatment during differentiation … of perilipin A, leptin and leptin-related pathway, such as leptin receptor, Janus kinase 2 and suppressor of cytokine signaling-3 (after 0.0 and ….00 ± 0.03) vs. (0.35 ± 0.05) , (1.00 ± 0.06) vs. (0.34 ± 0.05) , P<0.001).
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]  •  2016  |  View Paper
No treatment effects were observed in adipocytes from the high-energy diet groups, neither in leptin expression nor secretion, except that leptin secretion was significantly reduced by leucine in RE fish adipocytes (p=0.025).
General and comparative endocrinology  •  2015  |  View Paper
Cathepsin L expression and activity were both significantly increased by leptin whereas a cathepsin L peptide inhibitor or siRNA specific for CUX1 completely prevented the leptin-induced increase in FTO expression.
PloS one  •  2013  |  View Paper
Collectively, these results suggest that leptin and leucine synergistically regulate protein metabolism in skeletal muscles both in vitro and in vivo.
There were interactions (P< 0·05) between the leucine and leptin treatments with regard to protein metabolism in C2C12 myotubes and soleus muscles of ob/ob mice but not in the gastrocnemius muscles of ob/ob mice.
British Journal of Nutrition  •  2012  |  View Paper
L-leucine and L-glutamate also strongly stimulated leptin synthesis and secretion.
Biochemistry and cell biology = Biochimie et biologie cellulaire  •  2006  |  View Paper
Leu and norleucine stimulated a rise in plasma leptin ; however, the magnitude was less than the response to a complete meal.
American journal of physiology. Endocrinology and metabolism  •  2006  |  View Paper
VSMC size and [3H]leucine incorporation rates were significantly increased by leptin in stretched and unstretched tissues.
Journal of Pharmacology and Experimental Therapeutics  •  2005  |  View Paper
Therefore, we concluded that leucine activates leptin expression in adipose cells at the level of translation via a mammalian target of rapamycin (mTOR)-mediated pathway.
We found that addition of leucine to isolated rat adipocytes significantly increased leptin production by these cells, suggesting that postprandial leptin levels may be directly regulated by dietary leucine.
American journal of physiology. Endocrinology and metabolism  •  2003  |  View Paper
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