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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Geldanamycin
Research Papers that Mention the Interaction
“ Leu-Ile elicited an increase in cAMP response element binding protein (CREB) phosphorylation, which was inhibited by GA , indicating that CREB is a downstream target of Hsp90/Akt signaling.”
An Analog of a Dipeptide-Like Structure of FK506 Increases Glial Cell Line-Derived Neurotrophic Factor Expression through cAMP Response Element-Binding Protein Activated by Heat Shock Protein 90/Akt Signaling Pathway“Here we report that geldanamycin , a specific inhibitor of heat shock protein 90, hampers the refolding of L after membrane translocation and completely prevents the cleavage of SNAREs.”
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals
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