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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Leucine and Colforsin

supplement:

Leucine

Research Papers that Mention the Interaction

0.01-1 microM FSK had no effect on up-modulated currents, whereas high FSK rapidly and reversibly inhibited ICa, L by < or = 42% without affecting ICl.
High FSK also inhibited ICa, L in myocytes dialyzed with protein kinase A inhibitor.
Short (2-3 min) exposures to higher concentrations (10-100 microM) of FSK frequently had a multiphasic effect on ICa, L ; marked stimulation during the first minute quickly faded during the next 1-2 min, and removal of the drug caused secondary stimulation that lasted for several minutes.
We conclude that FSK inhibits cardiac ICa, L by reducing the availability of Ca2+ channels.
Molecular pharmacology  •  1996  |  View Paper
Forskolin considerably increased the electrical and secretory effects of leucine.
Forskolin had little effect on 86Rb+ efflux, consistently potentiated insulin release but induced electrical activity only in the presence of leucine.
The Journal of physiology  •  1986  |  View Paper
Treatment with rolipram (10 μM) and forskolin (5 μM) for 25 min decreased L p to 37% of control.
American journal of physiology. Heart and circulatory physiology  •  1998  |  View Paper