“ Cisapride also delayed the kinetics of recovery of I(Ca, L ) from inactivation.”
“ Cisapride elicited a tonic block and a use-dependent block of I(Ca, L).”
“The inhibitory effect of cisapride on I(Ca, L ) might play an important role in its cardiotoxicity under pathophysiological conditions, such as myocardial ischemia.”
“These blocking effects were voltage dependent as the degree of inhibition at -40 mV was greater than that at -70 mV. Cisapride shifted the steady-state inactivation curve of I(Ca, L ) in the negative direction, but had no effect on the steady-state activation curve.”