Possible Interaction: Leucine and Atorvastatin

“AF inducibility in SHRs was higher after atrial burst pacing, … a decrease in the L-type calcium current (ICa L ), an increase in the transient outward K+ current (Ito) and ultra-rapid delayed rectifier …+ current (IKur), and a shortened action potential duration (APD), which could be inhibited by atorvastatin.”

“A 9-month course of atorvastatin 40mg per day only partially reduced the patient’s cholesterol, with total serum cholesterol dropping to 10.8 mmol/ L and LDL cholesterol to 9.19 mmol/L, without improvement of his xanthomas.”

“The lipid lowering trials have … a more aggressive strategy using atorvastatin 80 mg daily aiming for an LDL cholesterol of … mmol/L (i.e. less than 2.0 mmol/ L ) with a standard approach setting a target of 2.6 … equating usually to a 25 to 35% LDL reduction.”