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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
supplement:
Arctigenin
Research Papers that Mention the Interaction
“In DSS-induced mice, the inhibition of Th1/Th17 responses and anti-colitis effect of arctigenin were abrogated by leucine treatment.”
“Interestingly, the inhibitory effect of arctigenin on T cell differentiation disappeared under a status of mTORC1 overactivation via knockdown of tuberous sclerosis complex 2 (TSC2, a negative regulator of mTORC1) or pretreatment of leucine (an agonist of mTOR).”
Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway.“ Arctigenin inhibited INa and ICa, L and attenuated the aconitine-increased INa and ICa,L by accelerating the activation process and delaying the inactivation process.”
“In the context of electrophysiology, INa, ICa, L , and Ito may be multiple targets of arctigenin , leading to its antiarrhythmic effect.”
Arctigenin, a Potential Anti-Arrhythmic Agent, Inhibits Aconitine-Induced Arrhythmia by Regulating Multi-Ion Channels
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