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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“It has been shown that L-leucine is transaminated in the presence of 2-oxoglutarate and subsequently decarboxylated by human term placenta.”
Leucine catabolism in human term placenta.“Furthermore, KIC and Leu , but not HIV, decreased state 3 using alpha-ketoglutarate.”
α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain“Plasma concentrations of proline and leucine were increased by AKG , whereas concentrations of taurine and glutamine were decreased.”
“Thus, in the presence of leucine , this enzyme is more responsive to high levels of glutamate and less responsive to inhibition by alpha-ketoglutarate.”
“ L-Leucine slightly decreased the rate of L-glutamine deamidation, inhibited the conversion of glutamate to 2-ketoglutarate by transamination, increased the oxidative deamination of L-glutamate, stimulated the recirculation of 2-ketoglutarate to glutamate and inhibited the further oxidative metabolism of 2-ketoglutarate.”
“High concentrations of 2-ketoglutarate strongly inhibited valine, isoleucine, and alanine transaminations but were less inhibitory for leucine and aspartate transaminations.”
Characterization of amino acid aminotransferases of Methanococcus aeolicus
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