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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Furthermore, we wanted to explore if glucagon‐like peptide‐1 (GLP‐1), isosteviol (ISV) and 5‐aminoimidazole‐4‐carboxamide 1‐β‐d‐ribofuranoside (AICAR) counteract changes in α‐cell function induced by chronic exposure to leucine.”
Impact of glucagon‐like peptide‐1 (7‐36) amide, isosteviol and 5‐aminoimidazole‐4‐carboxamide 1‐β‐d‐ribofuranoside on leucine‐mediated α‐cell dysfunction“ AICAR also prevented the hyperphosphorylation of eukaryotic initiation factor (eIF) 4E binding protein (4E-BP1), ribosomal protein S6 kinase (S6K1), S6, and eIF4G in response to leucine , suggesting a decrease in mTOR activity.”
“Applying 5-aminoimidazole-4-carbox-amide 1-beta-d-ribonucleoside , an activator of AMPK, abolished the stimulation of mTOR signaling by leucine , showing that AMPK negatively controls mTOR signaling.”
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