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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Leptin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Mice with deletion of the O-GlcNAcase gene, either via whole-body heterozygous deletion or through adipocyte-targeted homozygous deletion, exhibited increased O-GlcNAc levels in adipose tissue and increased leptin levels that were inhibited by iron.”
“Of note, iron increased the occupancy of pCREB and decreased the occupancy of O-GlcNAcylated CREB on the leptin promoter.”
“The increased leptin levels induced by glucosamine were susceptible to the inhibition by iron , but in the case of OGT inhibition, iron did not further decrease leptin.”
Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB“Treatment of 3T3-L1 adipocytes with iron decreased leptin mRNA in a dose-dependent manner.”
“In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription.”
“It has been proposed that iron influences the satiety hormone leptin ; however, a direct link between iron and leptin has remained elusive.”
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