Possible Interaction: Leptin and Calcium Supplement

“A positive correlation was found between leptin concentration and MAR, protein, calcium , potassium NAR and consumption of dairy products in term mothers (p<0.05).”

“The effect of leptin on intracellular calcium was inhibited in a dose-dependent manner by incubation with U73122 and AACOCF3, but not … that leptin is able to enhance ADP-induced aggregation of human platelets, and raise the possibility that PLC, PKC, PLA2, and calcium could play … action of leptin.”

“ Leptin increases platelet free calcium in a dose-dependent manner.”

“Similarly, the incubation with leptin induced a significant and dose-dependent increase in platelet free calcium , which was blunted in overweight and obese patients.”

“These findings suggest that signaling pathway other than JAK–STAT tyrosine phosphorylation (ie PLC and calcium ) may be involved in mediating the prothrombotic action of leptin.”

“Although leptin had no direct effect on mitochondrial integrity, it profoundly enhanced the ability of calcium to induce mitochondrial swelling, an effect partially reversed by an OBR antagonist.”

“Elevated serum concentrations of calcium and 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] in untreated ob/ob mice showed sharp reduction with leptin administration (4 mg/kg, i.p.”

“It was found that leptin decreased CA III expression while insulin increased it which suggests that the decrease in CA III expression observed in obesity in rat adipose tissue may be related to hyperleptinemia.”

“ Leptin also enhanced calcium ionophore-stimulated release of free arachidonic acid.”

“Thus, leptin suppresses renal gene overexpression for 1 alpha-hydroxylase and 24-hydroxylase and corrects increased serum concentrations of calcium and phosphate in ob/ob mice.”

“ Leptin modulated Ca2+ signals in acutely isolated arcuate neurons.”

“Compared with … medium, intracellular calcium content was significantly increased … VSMCs treated by leptin (200, 400 and 800 ng/ml) combined with calcification medium [11.99 ± 3.63, 15.18 ± 4.55, … 24.14 ± 5.85 mg/ml, respectively, vs 7.27 ± 1.54 mg/ml, all p<0.01].”