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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Leptin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In contrast, AVP administration, while also increasing ACTH and cortisol, significantly suppressed leptin , more so in the women than in the men.”
Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls“Previous work has shown that leptin appears to regulate the plasma levels of hormones such as adrenocorticotropic hormone (ACTH) and cortisol in humans and that it has antidepressant effects in animals.”
“Secretion of ACTH correlated with leptin (R = 0.63; P = 0.0001) and insulin (R = 0.67; P = 0.0001).”
“In all the observed subjects (n = 20), we noted positive correlations between baseline values of leptin and ACTH , as well as negative correlation between basal concentrations of leptin and mobilisation of cortisol.”
“ Corticotropin (ACTH)-induced adrenal aldosterone, cortisol, and dehydroepiandrosterone secretion was inhibited by leptin in a concentration-dependent manner, whereas this hormone had no significant effect on catecholamine release by primary cultures of human adrenal chromaffin cells.”
“We also show an inverse relation between rapid fluctuations in plasma levels of leptin and those of adrenocorticotropic hormone (ACTH) and cortisol that could not be accounted for on the basis of glucocorticoid suppression of leptin.”
“Thus, the timing of ACTH exposure, followed by decreased leptin receptor mRNA, converged with the timing of decreased GH secretion under the influence of leptin with ACTH.”
Changes in growth hormone secretion and leptin receptor mRNA expression under the influence of leptin and adrenocorticotropin in pituitary cells of early weaned ewe lambs.“Treatment with ACTH increased leptin concentrations in AUG only, whereas insulin concentrations increased in JAN only.”
“ ACTH injection resulted in a 2.9-fold increase (P=0.164) in leptin which preceded a 3.2-fold increase (P=0.0290) in cortisol by 105 min in summer.”
“The data indicate that ACTH stimulates leptin production earlier than cortisol in both summer and winter, and that while the leptin response appears most variable in summer, fecal corticosteroids are most variable in winter.”
“The peptide hormone ACTH stimulates lipolysis and suppresses leptin production in adipocytes via the G protein-coupled receptor, melanocortin 2 receptor (MC2-R).”
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