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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Lentinan
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Results We found that lentinan inhibits the production of pro-inflammatory cytokines, including IL-1β, TNF-α, IL-8 and the secretion of PGE2 and NO , by reducing the expression of COX-2 and iNOS in AGE-challenged chondrocytes.”
Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes“However, LNT significantly increased cell viability and effectively attenuated STZ‐induced ROS production, iNOS expression and nitric oxide release and the activation of JNK and p38 MAPK in a dose‐dependent manner in vitro.”
Lentinan protects pancreatic β cells from STZ‐induced damage“Results: Lentinan inhibits NO and TNF-α secretion and phosphorylation of MAP kinases JNK1/2 and ERK1/2.”
“ Lentinan increased splenocyte NO production and cytosolic-free calcium concentration in a dose-dependent manner (P < 0.001).”
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