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Possible Interaction: Lentinan and Aldesleukin



Research Papers that Mention the Interaction

The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan , when compared with that before lentinan injection.
International journal of immunopharmacology  •  1992  |  View Paper
On the other hand, percentage of CD8+CD11- cells were significantly increased and production of IL-2 was markedly enhanced after the local injection of Lentinan.
Nihon Geka Gakkai zasshi  •  1991  |  View Paper
The results indicated that lentinan of above mentioned concentrations did not obviously promote the lymphocyte proliferation, but increased the secretion of IL-2 and IFN-γ and enhanced the expression of lymphocyte surface markers CD4 and CD8 in microgravity environment.
Zhongguo shi yan xue ye xue za zhi  •  2012  |  View Paper
Improvements of antitumor effects by the combination of lentinan and IL-2 were also observed in the MBL-2/B6 and S908.D2/B10.D2 systems.
Cancer Immunology, Immunotherapy  •  2005  |  View Paper
From these results we conclude that IL-2 and lentinan in combination are more effective than either one alone for inducing destruction of pulmonary metastases.
with lentinan became cytotoxic on in vitro treatment with IL-2.
IL-2 … lentinan was also observed in mice bearing spontaneous lung micrometastases: neither IL-2 (<5×104 U/mouse) nor lentinan (<2.5 mg/kg) alone … a therapeutic effect, but multiple injections of IL-2 with a single injection of lentinan resulted in significant inhibition of spontaneous pulmonary metastases.
Cancer Immunology, Immunotherapy  •  2004  |  View Paper
Furthermore, combination therapy with lentinan and IL-2 achieved complete tumour regression in all the mice transplanted with S908.D2 progressed tumour lines, although IL-2 alone did not show any anti-tumour effects in either the S908.D2 parental or progressed lines.
British Journal of Cancer  •  1996  |  View Paper
Synergistic effects were observed between pre‐ and post‐operative treatments with lentinan and IL‐2 : 8 of 12 mice were completely cured.
Japanese journal of cancer research : Gann  •  1994  |  View Paper
3) Preoperative endoscopic intratumoral injection combined IL-2 and Lentinan or OK-432 induced immunocytes including antigen-presenting cells in the site of the gastric cancer, and increased the IL-2R and the LAK activity of PBL.
Nihon Geka Gakkai zasshi  •  1991  |  View Paper
Furthermore, combined administration of lentinan and IL-2 was found to augment the endogenous LAK activity even in the tumor bearer, and show a substantial inhibition of tumor growth and a significant increase in survival rate in the C3H/HeN/MM46 system.
Surface marker analysis of endogenous … a combined administration of lentinan … IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK … NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.
International journal of immunopharmacology  •  1990  |  View Paper
Oral administration of LTN apparently modulates the systemic immune function through T cell stimulation , especially Th cells, but continued administration may induce a tolerance to the effect of LTN.
Nihon Gan Chiryo Gakkai shi  •  1989  |  View Paper
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