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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Lauric Acid
drug:
Propylene Glycol
Research Papers that Mention the Interaction
“Capric acid and dodecylamine, but not lauric acid or neodecanoic acid, increased the skin permeation rate of PG , suggesting that enhanced solvent penetration could also be involved as a mechanism for increased skin permeation of the drug.”
Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines“We found that the addition of lauric acid to propylene glycol dramatically improves the penetration of the drugs, measured by the drug's ED(50).”
Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain.“ Lauric acid (12:0) enhanced the absorption depending on its concentration in PG and showed a maximal enhancement at 10% w/w.”
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