Possible Interaction: Lauric Acid and Propranolol

“Furthermore, the apparent partition coefficient of PL in an n-octanol/buffer system was significantly increased at a 1:1 molar ratio to lauric acid compared with that of PL alone.”

“However, the Js value of PL was decreased at increased molar ratios (e.g., 3:1) of lauric acid.”

“ Lauric acid , at a fatty acid: PL molar ratio of 1:1, produced the largest increase in permeation rate (Js), penetration coefficient and partition coefficient of PL.”

“ PL flux was increased 2.5-fold in the presence of lauric acid compared to that without the fatty acid.”

“ PL absorption from Witepsol and macrogol suppositories with lauric acid at a 1:1 molar ratio was much larger than that after PL alone and the 1:2 or 1:3 molar ratio ones.”

“These results supported the concept that a portion of PL , by forming a 1:1 complex with lauric acid , would penetrate across the rectal mucosa more easily than PL alone.”

“Comparison of the NMR spectra of PL, lauric acid, and the mixture suggested that the carbonyl group of lauric acid interacted with the amino and hydroxyl groups of PL , probably by charge interaction.(ABSTRACT TRUNCATED AT 250 WORDS)”

“The IR spectra of the mixture of PL with lauric acid (molar ratio, 1:1) was characterized by an extreme shift of the CO peak.”

“The plasma PL concentrations were significantly higher and more sustained after a single percutaneous application of the formulation with lauric acid than those after the formulation without the acid.”

“ Propranolol formed 1:1 molar addition compounds with both lauric and capric acids; the addition compound produced from propranolol and lauric acid (m.p.”