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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Lauric Acid
drug:
Imatinib
Research Papers that Mention the Interaction
“Specific inhibition of c‐Abl by imatinib , siRNA, or c‐Abl kinase dead drastically reduces high NaCl‐induced TonEBP/OREBP activity by reducing its nuclear location and transactivating activity.”
c‐Abl mediates high NaCl‐induced phosphorylation and activation of the transcription factor TonEBP/OREBP“Furthermore, inhibition of c‐Abl with imatinib preserved Purkinje neurons and reduced general cell apoptosis in the cerebellum, improved neurological symptoms, and increased the survival of NPC mice.”
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann‐Pick type C disease
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