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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Lauric Acid
supplement:
D-Serine
Research Papers that Mention the Interaction
“Moreover, since DAO also metabolises other D-amino acids,1 D-serine is not the only substrate that might be affected by an increase in DAO activity.”
“… DAO … D-serine and, other things being equal, contribute to a reduced synaptic availability of D-serine, potentially impairing NMDAR function.1 As such, our findings … synthesis by serine racemase,6,9 and its release and reuptake.10 Alterations in these processes could counteract – or exacerbate – enhanced DAO activity.”
D-Amino acid oxidase activity and expression are increased in schizophrenia“ DAO controls the level of D-serine , which accumulates in the spinal cord in cases of sporadic ALS and in a mouse model of ALS, indicating that this abnormality may represent a fundamental component of ALS pathogenesis.”
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase“D-amino acid oxidase DAO , DAAO) degrades the NMDA receptor co-agonist D-serine , modulating D-serine levels and thence NMDA receptor function.”
D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine
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