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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Lapatinib
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Centrally acting agents, which suppress ACTH secretion, include cabergoline, octreotide, as well as the investigational agents pasireotide, bexarotene, and lapatinib , which are being studied in patients with pituitary tumors.”
Advances in medical therapies for Cushing's syndrome.“ Lapatinib decreased proopiomelanocortin (Pomc) mRNA levels and ACTH levels in AtT-20 cells and also inhibited cell proliferation, induced apoptosis, and decreased pituitary tumor-transforming gene 1 (Pttg1), a hallmark of pituitary tumors, mRNA levels.”
“Thus, lapatinib decreases the ACTH production and proliferation of corticotroph tumor cells.”
Lapatinib decreases the ACTH production and proliferation of corticotroph tumor cells.
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