“Binding constant (Kb) of 5.74×103 and number of binding site of 0.97 showed that there is a slight interaction between lamotrigine and HSA.”
“… lamotrigine … HSA in the studied concentrations was not as much as many other drugs, but the secondary structure of the HSA was significantly changed following the … α-helix percentage was reduced from 67% to 57% after the addition of lamotrigine in the molar ratio of 4:1 to HSA.”