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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Lactulose
drug:
Chenodeoxycholate
Research Papers that Mention the Interaction
“ Lactulose reduced dehydroxylation of chenodeoxycholic acid to the potentially toxic secondary bile acid lithocholic by over 90%.”
Faecal steroids and colorectal carcinogenesis.“These results show that it is possible to maintain viable intestinal bacteria in vitro using a continuous culture chemostat and that the cultures respond to changing conditions as evinced by the inhibition of 7 alpha-dehydroxylation of chenodeoxycholic acid on addition of lactulose.”
“Oral administration of 750 mg chenodiol is associated with increased small intestinal permeability to lactulose in humans, supporting the possibility that this drug may also cause acute small intestinal mucosal injury.”
“Results show that chenodeoxycholate , starting at the concentration of 0.1 mM, enhanced in a doserelated manner the trans epithelial flux of lactulose in the ileum.”
Bile acids reversible effects on small intestinal permeability“ Lactulose reduced dehydroxylation of chenodeoxycholic acid to the potentially toxic secondary bile acid lithocholic by over 90%.”
Faecal Steroids and Colorectal Carcinogenesis.
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