Possible Interaction: Kynurenic Acid and Tyrosine

“The results of a comparison of the absolute contents of catecholamines, as wel las the ratio between the contents … transmitter and the levels of the transmitter in the appropriate nervous terminals are the base to suggest that kynurenic acid … tyrosine into dopamine, increases its transport … decreases the noradrenergic transmission.”

“Ten out of 19 amino acids (specifically, leucine, isoleucine, phenylalanine, methionine, tyrosine , alanine, cysteine, glutamine, glutamate, and aspartate) significantly reduced KYNA formation at 1 mmol/L. These amino acids showed inhibitory effects in a dose-dependent manner, and partially inhibited KYNA production at physiological concentrations.”