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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Kynurenic Acid
supplement:
Serine
Research Papers that Mention the Interaction
“ D‐serine (100 μ) reversed the ability of KYNA to block the excitatory effects of NMDA, suggesting that KYNA attenuates NMDA‐induced excitation of SNc DA neurons via blockade of the GLY allosteric site on the; NMDA receptor.”
Excitatory amino acid‐induced excitation of dopamine‐containing neurons in the rat substantia nigra: Modulation by kynurenic acid“Pretreatment of the mice with D‐serine (100 μg intracerebroventricularly), a glycine agonist and a competitive antagonist of KYNA , completely prevented the anticonvulsive action of NAL.”
“4 Similar … of d‐serine were also able to block the anticonvulsant … of the non‐selective glycine receptor antagonist, kynurenic acid , against seizures induced by NMDLA, but were without effect on the anticonvulsant effect of … competitive NMDA receptor antagonist, 3‐((+)‐2‐carboxypiperazin‐4‐yl)‐propyl‐1‐phosphonic acid (CPP).”
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