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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Kynurenic Acid and Serine

supplement:

Serine

Research Papers that Mention the Interaction

D‐serine (100 μ) reversed the ability of KYNA to block the excitatory effects of NMDA, suggesting that KYNA attenuates NMDA‐induced excitation of SNc DA neurons via blockade of the GLY allosteric site on the; NMDA receptor.
Synapse  •  1994  |  View Paper
Pretreatment of the mice with D‐serine (100 μg intracerebroventricularly), a glycine agonist and a competitive antagonist of KYNA , completely prevented the anticonvulsive action of NAL.
Journal of neurochemistry  •  1992  |  View Paper
4 Similar … of d‐serine were also able to block the anticonvulsant … of the non‐selective glycine receptor antagonist, kynurenic acid , against seizures induced by NMDLA, but were without effect on the anticonvulsant effect of … competitive NMDA receptor antagonist, 3‐((+)‐2‐carboxypiperazin‐4‐yl)‐propyl‐1‐phosphonic acid (CPP).
British journal of pharmacology  •  1990  |  View Paper