Possible Interaction: Kynurenic Acid and Leucine

“ KYNA synthesis was strongly reduced in the presence of leucine (Leu), and the uptake of [14C]Leu was inhibited by the KYNA precursor KYN, which points to Leu as a potential endogenous modulator of KYNA formation in CNS cells.”

“Ten out of 19 amino acids (specifically, leucine , isoleucine, phenylalanine, methionine, tyrosine, alanine, cysteine, glutamine, glutamate, and aspartate) significantly reduced KYNA formation at 1 mmol/L. These amino acids showed inhibitory effects in a dose-dependent manner, and partially inhibited KYNA production at physiological concentrations.”