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Last Updated: 2 years ago

Possible Interaction: Kynurenic Acid and Glutamate

supplement:

Glutamate

Research Papers that Mention the Interaction

Pretreatments with the non-selective ionotropic glutamatergic-receptor antagonist kynurenic acid or the selective NMDA receptor antagonists AP-7 and LY235959 significantly reduced the hypotensive response to microinjection of L-glu in the LH.
Brain Research  •  2005  |  View Paper
Aortic kynurenic acid production was diminished by modification of the ionic milieu, hypoxia and hypoglycemia, as well as by L-glutamate and L-aspartate, endogenous glutamate receptor agonists, and aminooxyacetic acid, a non-selective inhibitor of aminotransferases and mitochondrial respiration.
European journal of pharmacology  •  2002  |  View Paper
Aminooxyacetic acid, non-selective aminotransferase inhibitor, and L-glutamate , but neither N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-metyloisoxazolo-4-propionate (AMPA), nor kainate, diminished synthesis of KYNA.
Brain Research  •  2000  |  View Paper
Prior injection of kynurenic acid (0.1 micromol), a broad spectrum antagonist of ionotropic excitatory amino acid receptors, completely blocked the circulatory effects of L-proline, significantly reduced those of L-glutamate but had little effect on responses to L-arginine.
Neuroscience Letters  •  1999  |  View Paper
KYN (500 and 100 microM) and 7-Cl KYN (10 microM) blocked evoked release of NE by L-GLU (1 mM).
The inhibitory effects of 100 microM KYN on evoked release of NE by L-GLU were reversed by 10 microM and 100 microM D-SER and, but not 10 or 100 microM GLY.
Brain Research  •  1994  |  View Paper
The spider toxin Argiotoxin636 (threshold 10(-11) M), 2-amino-4-phosphonobutyric acid (AP-4), glutamic acid diethyl ester (GDEE), gamma-D-glutamylaminomethyl-sulfonic acid (GAMS), and kynurenic acid decreased the resting activity and effectively blocked or reversed the effect of L-glutamate and its non-NMDA agonists.
Brain Research  •  1994  |  View Paper
The excitatory effect of L-glutamate on PGCL sympathoexcitatory neurons was blocked by iontophoretic applications of kynurenic acid , whereas identical amounts of 8-OH kynurenic acid were ineffective.
The American journal of physiology  •  1986  |  View Paper
In addition, on a number of cells kynurenic acid reduced the depolarization evoked by L-glutamate by an equivalent amount and it is thus proposed that the synaptic transmitter is glutamate-like.
Neuroscience Letters  •  1986  |  View Paper