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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Kynurenic Acid
supplement:
D-Serine
Research Papers that Mention the Interaction
“Co-infusion of KYNA with the α7nAChR agonist galantamine (5 µM), but not with the NMDA receptor agonist D-serine (100 nM), prevented this effect.”
Kynurenic acid leads, dopamine follows: A new case of volume transmission in the brain?“The inhibitory effects of 100 microM KYN on evoked release of NE by L-GLU were reversed by 10 microM and 100 microM D-SER and, but not 10 or 100 microM GLY.”
“The reduction of NMDA responses by kynurenic acid was reversed by D-serine , and quisqualic acid competitively inhibited kainic acid-evoked release.”
“Our results support the following conclusions: 1) kynurenine (0.1 or 0.2 mumol, ICV) results in slight stereotypy and ataxia, but the … kynurenic acid-induced behavioral abnormalities is correlated with the length of disappearance of micro-injected kynurenic acid from brain tissue; 3) D-serine … ICV kynurenic acid ….”
“ D-serine caused a concentration-dependent enhancement of the NMDA response, an effect which was competitively inhibited by 7-chloro kynurenic acid (pA2 = 6.0).”
“In addition, 7-chloro kynurenic acid induced a concentration-dependent, non-competitive inhibition of the NMDA response per se, even in the absence of added D-serine.”
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