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Last Updated: 2 years ago

Possible Interaction: Kynurenic Acid and D-Serine

supplement:

D-Serine

Research Papers that Mention the Interaction

Co-infusion of KYNA with the α7nAChR agonist galantamine (5 µM), but not with the NMDA receptor agonist D-serine (100 nM), prevented this effect.
Journal of Neural Transmission  •  2006  |  View Paper
The inhibitory effects of 100 microM KYN on evoked release of NE by L-GLU were reversed by 10 microM and 100 microM D-SER and, but not 10 or 100 microM GLY.
Brain Research  •  1994  |  View Paper
The reduction of NMDA responses by kynurenic acid was reversed by D-serine , and quisqualic acid competitively inhibited kainic acid-evoked release.
Journal of neurochemistry  •  1991  |  View Paper
Our results support the following conclusions: 1) kynurenine (0.1 or 0.2 mumol, ICV) results in slight stereotypy and ataxia, but the … kynurenic acid-induced behavioral abnormalities is correlated with the length of disappearance of micro-injected kynurenic acid from brain tissue; 3) D-serine … ICV kynurenic acid ….
Brain Research Bulletin  •  1990  |  View Paper
D-serine caused a concentration-dependent enhancement of the NMDA response, an effect which was competitively inhibited by 7-chloro kynurenic acid (pA2 = 6.0).
In addition, 7-chloro kynurenic acid induced a concentration-dependent, non-competitive inhibition of the NMDA response per se, even in the absence of added D-serine.
European journal of pharmacology  •  1989  |  View Paper