supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Ketoprofen
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Stereoselectivity was high for the binding of ketoprofen to HSA and RSA.”
Species-dependent stereoselective drug binding to albumin: a circular dichroism study.“The two highest levels of oxidation of HSA (CT10-HSA, CT50-HSA) resulted in conformational changes with an increased exposure of hydrophobic regions, decreased high-affinity bindings of warfarin and ketoprofen and a reduced esterase-like activity.”
“Interestingly, a greater shift in the transition curve of HSA was observed in the presence of ketoprofen compared to diazepam.”
“Furthermore, the binding ability of HSA to warfarin and ketoprofen was more effectively decreased by methylglyoxal modification than the other aldehydes.”
“The results suggest a fast binding of ketoprofen to HSA and a fast dissociation of the formed complex, which are consistent with the reversible binding property of drug and HSA (k(-1) in the order of s(-1)).”
“However, high–affinity binding of ketoprofen to CT– HSA and, especially, MCO–HSA was diminished.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback