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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ketoconazole
supplement:
Vitamin D
Research Papers that Mention the Interaction
“The impact of bioactivation enzymes was shown upon the addition of ketoconazole (10 &mgr;M KTZ), a pan‐CYP inhibitor, which reduced the apparent potency of 25(OH)D3 and increased the EC50 from 272 to 608 nM in HEK293 cells.”
Strategies and limitations associated with in vitro characterization of vitamin D receptor activators“Stimulation of osteoblast differentiation in hMSCshi‐1α by 25(OH)D3 was prevented by ketoconazole and upon transfection with CYP27B1 siRNA.”
“Unlike 1,25(OH)2D3, the antiapoptotic effects of 25(OH)D3 on Bax and Bcl‐2 were blocked by the P450 inhibitor ketoconazole.”
“The hydroxylation of vitamin D3 to 1alpha,25(OH)2D3 is inhibited by the P-450 oxidase inhibitor ketoconazole.”
“ Ketoconazole is an imidazole antifungal that inhibits macrophage 1 alpha-hydroxylation of 25-hydroxyvitamin D3 and has been used in paraneoplastic hypercalcemia.”
“The velocity of the 1 alpha-hydroxylation reaction at ketoconazole concentrations of 0.01-1.0 mumol/L increased as the concentration of substrate 25-hydroxyvitamin D3 increased from 12-2000 nmol/L.”
“ Ketoconazole also inhibited the production of 24,25(OH)2D3 in cells in which this activity was induced by 1,24(OH)2D3.”
Effect of ketoconazole and miconazole on 25-hydroxyvitamin D3 metabolism by cultured chick kidney cells.“This study investigates whether vitamin D3 supplement can ameliorate the morphological changes induced by KZ.”
Vitamin D3 May Ameliorate the Ketoconazole Induced Adrenal Injury: Histological and Immunohistochemical Studies on Albino Rats
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